"Nucleotide-excision repair, DNA gap filling"

Across TCGA cell cohorts, RNA activity of the "Nucleotide-excision repair, DNA gap filling" pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCTN2, GJB6, and U2AF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Nucleotide-excision repair, DNA gap filling" activity versus TCTN2 in BLOOD_Leukemia (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TCTN2 →	-0.576	-0.166	.001	<.001	3	4
BLOOD_Lymphoma	GJB6 →	-0.067	-0.152	.001	.001	3	3
BLOOD_Myeloma	U2AF1 →	+1.500	+1.578	.003	.003	2	4
BLOOD_Leukemia	RNH1 →	+1.032	+0.201	.002	.003	3	3
OVARY	SNX16 →	-1.659	-1.291	.001	<.001	3	3
BLOOD_Leukemia	SMG6 →	-0.632	-0.126	.006	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006297 vs TCTN2 — BLOOD_Leukemia

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