Nucleotide-excision repair

Across TCGA patient cohorts, RNA activity of the Nucleotide-excision repair pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ILF2, TRIM28, and CHD4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleotide-excision repair activity versus ILF2 in COAD (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ILF2 →	+0.232	+0.025	<.001	<.001	3	8
LSCC	TRIM28 →	+0.324	+0.042	.001	<.001	3	7
LSCC	CHD4 →	+0.231	+0.044	<.001	<.001	3	7
LSCC	HNRNPU →	+0.277	+0.047	<.001	<.001	3	7
GBM	HNRNPUL1 →	+0.297	+0.030	<.001	.006	3	7
GBM	SMARCC2 →	+0.270	+0.033	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006289 vs ILF2 — COAD

Explore this scatter interactively →