Nucleotide-excision repair

Across TCGA cell cohorts, RNA activity of the Nucleotide-excision repair pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYBC1, VEZF1, and BRIP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYBC1 grouped by Nucleotide-excision repair-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CYBC1 →	+0.905	+0.183	<.001	<.001	3	5
LUNG_SCLC	VEZF1 →	+0.797	+0.127	.004	.009	3	5
LUNG_SCLC	BRIP1 →	+0.872	+0.158	.002	<.001	3	5
BLOOD_Leukemia	GNPAT →	+0.567	+0.196	.003	.001	3	4
BLOOD_Leukemia	MTMR10 →	+0.614	+0.239	<.001	<.001	3	4
BLOOD_Leukemia	RRM1 →	+0.737	+0.177	.003	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYBC1 by Nucleotide-excision repair activity — BLOOD_Leukemia

Explore this box plot interactively →