Nucleotide-excision repair

Across TCGA cell cohorts, RNA activity of the Nucleotide-excision repair pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are YTHDC2, PPWD1, and ORC3, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleotide-excision repair activity versus YTHDC2 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	YTHDC2 →	+1.309	+0.086	<.001	<.001	3	16
BLOOD_Myeloma	PPWD1 →	+1.152	+0.053	<.001	<.001	3	16
BREAST	ORC3 →	+0.768	+0.048	<.001	.002	3	16
BLOOD_Myeloma	RAD17 →	+0.857	+0.053	.001	<.001	3	16
LARGE_INTESTINE	S100PBP →	+1.185	+0.072	<.001	<.001	3	16
SKIN	DDX50 →	+0.767	+0.037	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006289 vs YTHDC2 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →