"Base-excision repair, gap-filling"

Across TCGA patient cohorts, RNA activity of the "Base-excision repair, gap-filling" pathway is significantly associated with the RNA expression of multiple genes, with the KIRP cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SFPQ, POLE, and ZC3H4, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Base-excision repair, gap-filling" activity versus SFPQ in KIRP (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRP	SFPQ →	+0.817	+0.046	<.001	<.001	3	34
GBM	POLE →	+1.084	+0.066	<.001	<.001	3	33
ACC	ZC3H4 →	+0.877	+0.046	<.001	<.001	3	32
KIRP	ACIN1 →	+0.746	+0.043	<.001	<.001	3	32
KICH	DIDO1 →	+0.819	+0.038	<.001	<.001	3	32
KIRP	LUC7L3 →	+1.321	+0.049	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006287 vs SFPQ — KIRP

Explore this scatter interactively →