"Base-excision repair, gap-filling"

Across TCGA cell cohorts, RNA activity of the "Base-excision repair, gap-filling" pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF4B, AKAP1, and COL5A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Base-excision repair, gap-filling" activity versus EIF4B in LIVER (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	EIF4B →	+0.995	+0.366	.004	.003	3	6
LUNG_NSCLC_LUAD	AKAP1 →	+0.651	+0.299	.005	.009	3	5
LIVER	COL5A1 →	-6.585	-0.422	<.001	.002	3	5
LIVER	HRH1 →	-2.244	-0.294	.004	.006	3	5
LIVER	MMACHC →	+1.216	+0.361	.001	<.001	3	5
BREAST	LIG3 →	+0.691	+0.193	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006287 vs EIF4B — LIVER

Explore this scatter interactively →