"Base-excision repair, gap-filling"

Across TCGA cell cohorts, RNA activity of the "Base-excision repair, gap-filling" pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FEN1, MTHFD1, and STMN1, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Base-excision repair, gap-filling" activity versus FEN1 in URINARY_TRACT (Pearson r = 0.76).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	FEN1 →	+2.037	+1.795	.002	.001	3	15
URINARY_TRACT	MTHFD1 →	+3.050	+1.575	<.001	.003	3	14
LARGE_INTESTINE	STMN1 →	+1.834	+0.611	.002	.005	3	14
SOFT_TISSUE	MCM4 →	+1.321	+0.218	.008	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	ZNF207 →	+1.276	+0.904	<.001	.003	3	14
UPPER_AERODIGESTIVE_TRACT	ANP32B →	+2.025	+1.334	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006287 vs FEN1 — URINARY_TRACT

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