"Base-excision repair, AP site formation"

Across TCGA patient cohorts, RNA activity of the "Base-excision repair, AP site formation" pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KIAA1143, PPP1R13L_S395, and SPIN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Base-excision repair, AP site formation" activity versus KIAA1143 in OV (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	KIAA1143 →	+0.354	+0.031	.005	.008	3	5
BRCA	PPP1R13L_S395 →	-0.821	-0.046	<.001	<.001	3	5
OV	SPIN1 →	+0.552	+0.044	<.001	<.001	3	4
OV	ADAM17_T735 →	-0.563	-0.036	.005	.003	3	4
OV	CIR1 →	+0.269	+0.024	.007	.008	3	4
OV	DOCK11_S12 →	-0.865	-0.042	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006285 vs KIAA1143 — OV

Explore this scatter interactively →