"Base-excision repair, AP site formation"

Across TCGA patient cohorts, RNA activity of the "Base-excision repair, AP site formation" pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAPK8IP3, INTS2, and DSN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Base-excision repair, AP site formation" activity versus MAPK8IP3 in BRCA (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MAPK8IP3 →	+0.624	+0.641	<.001	.002	3	3
UCEC	INTS2 →	+0.301	+1.111	.002	<.001	3	3
UCEC	DSN1 →	+0.696	+1.050	<.001	<.001	3	3
UCEC	LAS1L →	+0.294	+0.778	.001	.008	3	3
BRCA	POLR3K →	+0.511	+0.875	<.001	<.001	3	3
UCEC	TFDP1 →	+0.510	+0.901	.005	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006285 vs MAPK8IP3 — BRCA

Explore this scatter interactively →