Base-excision repair

Across TCGA patient cohorts, RNA activity of the Base-excision repair pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIG1, NCAPG, and FOXM1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Base-excision repair activity versus LIG1 in GBM (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LIG1 →	+0.635	+0.677	.001	<.001	3	6
GBM	NCAPG →	+1.058	+0.682	<.001	.002	3	6
GBM	FOXM1 →	+1.076	+0.641	<.001	.002	3	6
GBM	NCAPH →	+0.938	+0.670	<.001	.001	3	6
UCEC	HROB →	+0.732	+0.245	<.001	.002	3	6
GBM	SKA1 →	+1.072	+0.760	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006284 vs LIG1 — GBM

Explore this scatter interactively →