Base-excision repair

Across TCGA cell cohorts, RNA activity of the Base-excision repair pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF587B, MACROH2A2, and RTF2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF587B grouped by Base-excision repair-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZNF587B →	+1.067	+0.203	<.001	<.001	3	4
SKIN	MACROH2A2 →	-1.500	-0.259	.004	.004	2	5
LARGE_INTESTINE	RTF2 →	-0.530	-0.210	.005	.001	3	4
LARGE_INTESTINE	PLEKHH1 →	+1.995	+0.348	.001	<.001	3	4
LUNG_NSCLC_LUAD	FSD1 →	-1.168	-0.119	.003	.004	3	4
CNS	SEC14L1 →	-0.780	-0.228	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF587B by Base-excision repair activity — BREAST

Explore this box plot interactively →