Base-excision repair

Across TCGA cell cohorts, RNA activity of the Base-excision repair pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KHSRP, LIG3, and INCENP, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Base-excision repair activity versus KHSRP in STOMACH (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	KHSRP →	+0.909	+0.398	.008	<.001	3	9
SOFT_TISSUE	LIG3 →	+1.196	+0.383	.001	.004	3	7
LUNG_SCLC	INCENP →	+0.515	+0.219	.007	.003	3	7
BLOOD_Myeloma	BCL7A →	+1.750	+0.251	.009	<.001	3	6
BREAST	RNPS1 →	+0.618	+0.274	.002	<.001	3	6
LARGE_INTESTINE	TAF15 →	+0.711	+0.203	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006284 vs KHSRP — STOMACH

Explore this scatter interactively →