Transcription-coupled nucleotide-excision repair

Across TCGA patient cohorts, RNA activity of the Transcription-coupled nucleotide-excision repair pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FNDC3B, FLNA_S1459, and JUNB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcription-coupled nucleotide-excision repair activity versus FNDC3B in GBM (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FNDC3B →	-0.325	-0.024	.003	.007	3	6
OV	FLNA_S1459 →	-0.611	-0.036	.005	.003	3	5
OV	JUNB →	-0.305	-0.030	.006	.009	3	5
OV	MTA1 →	+0.359	+0.031	<.001	.008	3	5
CCRCC	C3AR1_S459 →	-0.392	-0.038	.005	.003	3	5
PDAC	S100A11_S6 →	-0.254	-0.023	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006283 vs FNDC3B — GBM

Explore this scatter interactively →