Transcription-coupled nucleotide-excision repair

Across TCGA patient cohorts, RNA activity of the Transcription-coupled nucleotide-excision repair pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NECTIN1, ST6GALNAC1, and TRPV4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcription-coupled nucleotide-excision repair activity versus NECTIN1 in BRCA (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NECTIN1 →	-0.610	-0.443	.006	.005	3	3
BRCA	ST6GALNAC1 →	-1.080	-0.410	.001	.009	3	3
OV	TRPV4 →	-0.534	-0.146	.005	.003	3	3
OV	SCARB2 →	-0.584	-0.211	.005	.002	3	3
GBM	SRGAP2C →	-0.426	-0.131	<.001	<.001	3	3
GBM	FA2H →	-0.963	-0.122	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006283 vs NECTIN1 — BRCA

Explore this scatter interactively →