Transcription-coupled nucleotide-excision repair

Across TCGA cell cohorts, RNA activity of the Transcription-coupled nucleotide-excision repair pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XAB2, ERCC2, and ZNF581, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcription-coupled nucleotide-excision repair activity versus XAB2 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	XAB2 →	+0.679	+0.085	.007	.001	2	15
URINARY_TRACT	ERCC2 →	+1.167	+0.079	<.001	<.001	3	14
BONE	ZNF581 →	+0.977	+0.087	<.001	.001	3	10
CNS	COLQ →	+0.298	+0.053	.009	.004	3	10
LIVER	CCDC80 →	+3.869	+0.098	.001	.006	2	10
STOMACH	CENPT →	+0.909	+0.138	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006283 vs XAB2 — UPPER_AERODIGESTIVE_TRACT

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