Regulation of DNA repair

Across TCGA cell cohorts, RNA activity of the Regulation of DNA repair pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF433, EFHB, and UGGT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF433 grouped by Regulation of DNA repair-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ZNF433 →	+1.380	+0.142	<.001	.002	3	5
STOMACH	EFHB →	+0.433	+0.154	<.001	.005	3	4
BLOOD_Leukemia	UGGT1 →	-0.615	-0.114	.009	.007	3	4
BLOOD_Leukemia	GBP2 →	+1.872	+0.173	<.001	<.001	3	4
KIDNEY	ZNF844 →	+1.187	+0.199	.001	.002	2	5
KIDNEY	CLDND1 →	+0.499	+0.209	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF433 by Regulation of DNA repair activity — STOMACH

Explore this box plot interactively →