Regulation of DNA repair

Across TCGA cell cohorts, RNA activity of the Regulation of DNA repair pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAR1B, ARID1A, and OPLAH, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of DNA repair activity versus SAR1B in LUNG_SCLC (Pearson r = -0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SAR1B →	-0.950	-0.174	<.001	<.001	3	7
BREAST	ARID1A →	+0.770	+0.141	.001	<.001	3	6
BREAST	OPLAH →	-1.439	-0.097	.002	.002	3	6
BLOOD_Lymphoma	PRDM2 →	+1.035	+0.120	.005	.002	3	5
STOMACH	AVPI1 →	-1.859	-0.265	.005	.002	2	6
STOMACH	KDM1A →	+1.073	+0.166	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006282 vs SAR1B — LUNG_SCLC

Explore this scatter interactively →