RNA-templated DNA biosynthetic process

Across TCGA patient cohorts, RNA activity of the RNA-templated DNA biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC1A, SMC3, and POGZ, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA-templated DNA biosynthetic process activity versus SMC1A in BRCA (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SMC1A →	+0.215	+0.021	<.001	.001	3	7
LSCC	SMC3 →	+0.211	+0.026	<.001	.001	3	7
HNSC	POGZ →	+0.282	+0.085	.001	<.001	3	7
HNSC	RAD21 →	+0.215	+0.059	<.001	.008	3	6
LSCC	ADNP →	+0.321	+0.036	.006	.004	3	6
LSCC	RPRD2 →	+0.206	+0.034	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006278 vs SMC1A — BRCA

Explore this scatter interactively →