RNA-templated DNA biosynthetic process

Across TCGA patient cohorts, RNA activity of the RNA-templated DNA biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CACNA2D2, HTR2A, and CRYBG1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA-templated DNA biosynthetic process activity versus CACNA2D2 in BRCA (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CACNA2D2 →	-0.952	-0.186	<.001	<.001	3	5
GBM	HTR2A →	-0.713	-0.121	<.001	<.001	3	5
GBM	CRYBG1 →	+0.860	+0.112	.001	.005	3	4
GBM	IQSEC1 →	-0.505	-0.136	.002	.002	3	4
HNSC	KIF1A →	-0.996	-0.165	.004	<.001	3	4
GBM	PART1 →	-0.408	-0.161	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006278 vs CACNA2D2 — BRCA

Explore this scatter interactively →