RNA-templated DNA biosynthetic process

Across TCGA cell cohorts, RNA activity of the RNA-templated DNA biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GMEB2, COPS7A, and SPTBN2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA-templated DNA biosynthetic process activity versus GMEB2 in OVARY (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	GMEB2 →	+0.468	+0.155	.002	.008	3	5
BLOOD_Leukemia	COPS7A →	-0.764	-0.094	<.001	.004	3	5
STOMACH	SPTBN2 →	+2.255	+0.215	.005	.007	3	5
BLOOD_Lymphoma	QARS1 →	+0.335	+0.104	.005	.009	3	5
SOFT_TISSUE	NELFCD →	+0.457	+0.224	.007	.003	3	4
PANCREAS	EML2 →	-1.045	-0.179	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006278 vs GMEB2 — OVARY

Explore this scatter interactively →