Regulation of DNA replication

Across TCGA patient cohorts, RNA activity of the Regulation of DNA replication pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INTS3, CNNM3, and METAP1D, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of DNA replication activity versus INTS3 in COAD (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	INTS3 →	+0.628	+0.542	<.001	.005	3	3
COAD	CNNM3 →	+0.455	+0.623	.008	.002	3	3
COAD	METAP1D →	+0.263	+0.582	.004	<.001	3	3
COAD	PPT2-EGFL8 →	+0.080	+0.681	.001	<.001	3	3
CCRCC	C19orf44 →	+0.448	+0.462	.001	.009	3	2
CCRCC	PHC1 →	+0.510	+0.622	.002	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006275 vs INTS3 — COAD

Explore this scatter interactively →