Regulation of DNA replication

Across TCGA cell cohorts, RNA activity of the Regulation of DNA replication pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WRAP53, PSMB6, and MFSD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WRAP53 grouped by Regulation of DNA replication-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	WRAP53 →	-0.721	-0.195	<.001	<.001	3	5
LARGE_INTESTINE	PSMB6 →	-0.824	-0.146	<.001	<.001	3	5
LIVER	MFSD1 →	+0.868	+0.176	<.001	.001	3	5
BREAST	IFI44 →	+2.538	+0.132	.002	.003	3	5
STOMACH	DDX60L →	+1.548	+0.135	.002	.004	3	5
LUNG_NSCLC_LUAD	NAE1 →	-0.512	-0.110	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WRAP53 by Regulation of DNA replication activity — CNS

Explore this box plot interactively →