DNA strand elongation involved in DNA replication

Across TCGA patient cohorts, RNA activity of the DNA strand elongation involved in DNA replication pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPM, MCM5, and GINS1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA strand elongation involved in DNA replication activity versus CENPM in UCEC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPM →	+0.942	+0.229	<.001	<.001	3	9
UCEC	MCM5 →	+1.031	+0.356	<.001	<.001	3	9
GBM	GINS1 →	+1.050	+0.446	<.001	<.001	3	9
UCEC	MCM4 →	+0.793	+0.337	<.001	<.001	3	9
GBM	EZH2 →	+1.137	+0.478	<.001	<.001	3	9
HNSC	KIF20A →	+1.178	+0.353	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006271 vs CENPM — UCEC

Explore this scatter interactively →