DNA strand elongation involved in DNA replication

Across TCGA cell cohorts, RNA activity of the DNA strand elongation involved in DNA replication pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM214B, ZNF839, and GBP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM214B grouped by DNA strand elongation involved in DNA replication-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	FAM214B →	+1.477	+0.133	<.001	.001	3	5
SOFT_TISSUE	ZNF839 →	+0.870	+0.122	.006	.007	2	5
PANCREAS	GBP1 →	+2.400	+0.133	<.001	<.001	3	4
PANCREAS	CD47 →	+1.551	+0.133	<.001	<.001	3	4
BLOOD_Leukemia	ZNF707 →	+0.545	+0.119	.006	.002	3	4
LUNG_NSCLC_LUSC	SHFL →	+1.213	+0.139	.004	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM214B by DNA strand elongation involved in DNA replication activity — OESOPHAGUS

Explore this box plot interactively →