"DNA replication, synthesis of primer"

Across TCGA patient cohorts, RNA activity of the "DNA replication, synthesis of primer" pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ORC1, MCM4, and SGO2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "DNA replication, synthesis of primer" activity versus ORC1 in UCEC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ORC1 →	+1.179	+0.585	<.001	<.001	3	8
LSCC	MCM4 →	+0.779	+0.594	<.001	<.001	3	7
LSCC	SGO2 →	+0.893	+0.729	<.001	<.001	3	7
LSCC	PRIM1 →	+0.885	+0.919	<.001	<.001	3	7
BRCA	MCM6 →	+0.916	+0.463	<.001	<.001	3	7
UCEC	CENPM →	+1.366	+0.562	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006269 vs ORC1 — UCEC

Explore this scatter interactively →