"DNA replication, synthesis of primer"

Across TCGA cell cohorts, RNA activity of the "DNA replication, synthesis of primer" pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR157, ZNF253, and SMAD7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "DNA replication, synthesis of primer" activity versus GPR157 in LUNG_SCLC (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GPR157 →	-1.525	-0.238	.009	.005	3	5
OESOPHAGUS	ZNF253 →	+1.390	+0.257	.001	.001	3	5
PANCREAS	SMAD7 →	-1.391	-0.665	.008	.001	3	4
LUNG_SCLC	RPS6KA4 →	-1.029	-0.313	<.001	<.001	3	4
OESOPHAGUS	ARRDC3 →	+1.167	+0.359	.005	.002	3	3
OESOPHAGUS	KLF16 →	-0.580	-0.336	.007	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006269 vs GPR157 — LUNG_SCLC

Explore this scatter interactively →