GO:0006268Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts
Across TCGA patient cohorts, RNA activity of the DNA unwinding involved in DNA replication pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.
The most reproducible pathway-associated proteins across cancer lineages are RFC2, RPL12_S38, and RRM1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.
Each partner is linked to its corresponding Q-omics profile.
Pathway-associated proteins by consensus
Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.