Mitochondrial DNA replication

Across TCGA patient cohorts, RNA activity of the Mitochondrial DNA replication pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNRNP200, UTP4, and WAPL, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial DNA replication activity versus SNRNP200 in LSCC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SNRNP200 →	+0.208	+0.063	<.001	<.001	3	7
LSCC	UTP4 →	+0.304	+0.056	<.001	<.001	3	7
LSCC	WAPL →	+0.219	+0.072	<.001	<.001	3	7
LSCC	DDX50 →	+0.234	+0.045	<.001	<.001	3	7
LSCC	DHX9 →	+0.230	+0.072	<.001	<.001	3	7
LSCC	GTF3C4 →	+0.404	+0.061	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006264 vs SNRNP200 — LSCC

Explore this scatter interactively →