Mitochondrial DNA replication

Across TCGA patient cohorts, RNA activity of the Mitochondrial DNA replication pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLG2, METTL23, and FOXK2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial DNA replication activity versus POLG2 in UCEC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	POLG2 →	+0.490	+0.278	.001	<.001	3	5
LSCC	METTL23 →	+0.325	+0.198	.001	.002	3	5
UCEC	FOXK2 →	+0.441	+0.200	.001	.009	3	4
UCEC	ZNF839 →	+0.313	+0.219	.009	.006	3	4
OV	TMEM97 →	+0.423	+0.200	.004	.005	3	4
PDAC	AHCY →	+0.235	+0.189	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006264 vs POLG2 — UCEC

Explore this scatter interactively →