Mitochondrial DNA replication

Across TCGA cell cohorts, RNA activity of the Mitochondrial DNA replication pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL38, MRPS23, and MRPL12, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial DNA replication activity versus RPL38 in LUNG_NSCLC_LUAD (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RPL38 →	-0.422	-0.103	.001	.005	3	6
BONE	MRPS23 →	-0.695	-0.177	.002	<.001	3	5
LUNG_NSCLC_LUAD	MRPL12 →	-0.511	-0.162	<.001	<.001	3	5
URINARY_TRACT	SOCS7 →	-0.626	-0.254	.006	.001	3	5
BREAST	C1S →	+3.148	+0.198	.002	.001	3	4
STOMACH	PPM1G →	-0.705	-0.156	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006264 vs RPL38 — LUNG_NSCLC_LUAD

Explore this scatter interactively →