DNA-templated DNA replication

Across TCGA cell cohorts, RNA activity of the DNA-templated DNA replication pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIAS3, SFXN3, and LYST, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PIAS3 grouped by DNA-templated DNA replication-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PIAS3 →	+0.811	+0.125	.002	.006	2	7
BREAST	SFXN3 →	+1.436	+0.147	.004	.006	3	5
BREAST	LYST →	+0.958	+0.153	.001	.002	3	5
BLOOD_Leukemia	MVP →	+1.529	+0.134	.004	.007	3	5
OESOPHAGUS	CNIH3 →	+1.546	+0.182	.001	.007	3	4
KIDNEY	MED7 →	+0.507	+0.153	.009	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PIAS3 by DNA-templated DNA replication activity — BREAST

Explore this box plot interactively →