Pyrimidine nucleotide catabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine nucleotide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGAX, PIK3R5, and FMNL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleotide catabolic process activity versus ITGAX in CCRCC (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ITGAX →	+0.691	+0.161	.004	<.001	3	5
BRCA	PIK3R5 →	+0.619	+0.198	<.001	.002	3	5
LSCC	FMNL1 →	+0.445	+0.193	.004	<.001	3	5
OV	TRIM2 →	-1.015	-0.279	<.001	<.001	2	5
LSCC	CLEC7A →	+0.578	+0.149	.007	.002	2	5
LUAD	FAM13C →	-0.357	-0.166	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006244 vs ITGAX — CCRCC

Explore this scatter interactively →