Pyrimidine nucleotide catabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine nucleotide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRPF8, PRORP, and DHRS4L2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRPF8 grouped by Pyrimidine nucleotide catabolic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PRPF8 →	+0.592	+0.767	.008	.006	3	4
BLOOD_Leukemia	PRORP →	+0.635	+0.765	.001	.008	3	4
BLOOD_Leukemia	DHRS4L2 →	+1.789	+1.232	.002	<.001	3	4
BLOOD_Leukemia	INCA1 →	+0.490	+1.005	<.001	.009	3	4
BLOOD_Myeloma	MAU2 →	-0.674	-0.963	.004	.005	3	3
OVARY	PRICKLE1 →	-1.796	-1.017	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRPF8 by Pyrimidine nucleotide catabolic process activity — OESOPHAGUS

Explore this box plot interactively →