UTP biosynthetic process

Across TCGA patient cohorts, RNA activity of the UTP biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNRIP1, KLHL24, and FNIP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, UTP biosynthetic process activity versus CNRIP1 in CCRCC (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CNRIP1 →	-0.552	-0.170	.001	<.001	3	3
OV	KLHL24 →	-0.430	-0.179	.001	<.001	3	3
OV	FNIP1 →	-0.574	-0.172	.001	.003	3	3
UCEC	RFC3 →	-0.803	-0.208	.002	.002	3	3
UCEC	CPNE8 →	-0.833	-0.288	<.001	<.001	3	3
GBM	CADM2 →	-1.324	-0.163	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006228 vs CNRIP1 — CCRCC

Explore this scatter interactively →