UTP biosynthetic process

Across TCGA cell cohorts, RNA activity of the UTP biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPTXR, LPCAT2, and SMPD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NPTXR grouped by UTP biosynthetic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NPTXR →	-2.110	-0.418	<.001	<.001	3	4
SOFT_TISSUE	LPCAT2 →	-1.459	-0.300	.008	<.001	3	4
SOFT_TISSUE	SMPD1 →	-1.270	-0.330	<.001	<.001	3	3
SOFT_TISSUE	CADM1 →	-3.717	-0.316	.009	.003	3	3
SOFT_TISSUE	FAM174B →	+1.801	+0.392	<.001	.001	3	3
LIVER	VASN →	-2.418	-0.339	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NPTXR by UTP biosynthetic process activity — SOFT_TISSUE

Explore this box plot interactively →