UTP biosynthetic process

Across TCGA cell cohorts, RNA activity of the UTP biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COX11, CAD, and ABCF2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, UTP biosynthetic process activity versus COX11 in PANCREAS (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	COX11 →	+1.155	+0.351	<.001	.002	3	6
BLOOD_Leukemia	CAD →	+0.448	+0.171	<.001	<.001	3	6
BLOOD_Leukemia	ABCF2 →	+0.564	+0.215	.007	<.001	3	5
STOMACH	SDC4 →	-3.663	-1.515	<.001	.003	3	5
LUNG_SCLC	TMEM177 →	+0.904	+0.298	.001	.001	3	5
BLOOD_Lymphoma	LDLR →	-1.005	-0.188	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006228 vs COX11 — PANCREAS

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