Pyrimidine nucleotide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine nucleotide biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MKI67, NCAPD2, and RRM2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleotide biosynthetic process activity versus MKI67 in BRCA (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MKI67 →	+0.724	+0.032	.001	<.001	3	7
BRCA	NCAPD2 →	+0.566	+0.027	.001	.003	3	7
HNSC	RRM2 →	+0.588	+0.081	<.001	<.001	3	6
OV	MCM2 →	+0.839	+0.032	<.001	.002	3	6
OV	MCM6 →	+0.924	+0.028	<.001	.009	3	6
PDAC	NCAPG →	+0.441	+0.023	.003	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006221 vs MKI67 — BRCA

Explore this scatter interactively →