Pyrimidine nucleotide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine nucleotide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TYMP, UBE2C, and PRR11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleotide biosynthetic process activity versus TYMP in LUAD (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TYMP →	+0.650	+0.131	.001	.006	3	5
PDAC	UBE2C →	+0.848	+0.143	<.001	.004	3	5
LSCC	PRR11 →	+0.476	+0.140	<.001	<.001	3	5
GBM	ZCCHC24 →	-0.657	-0.165	.005	<.001	3	5
LSCC	CDT1 →	+0.630	+0.141	.001	<.001	3	5
UCEC	KIF18A →	+0.787	+0.217	.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006221 vs TYMP — LUAD

Explore this scatter interactively →