Pyrimidine nucleotide biosynthetic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine nucleotide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AAAS, CSNK1G2, and BUB1B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleotide biosynthetic process activity versus AAAS in LUNG_NSCLC_LUAD (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	AAAS →	+0.548	+0.449	<.001	.005	3	5
BLOOD_Leukemia	CSNK1G2 →	+0.556	+0.179	.003	.002	3	5
BLOOD_Leukemia	BUB1B →	+1.240	+0.321	<.001	<.001	3	5
BLOOD_Leukemia	SNTB2 →	+1.169	+0.207	.001	<.001	3	5
SKIN	PCLAF →	+0.740	+0.187	.004	<.001	3	4
BLOOD_Leukemia	DHFR →	+0.923	+0.264	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006221 vs AAAS — LUNG_NSCLC_LUAD

Explore this scatter interactively →