Pyrimidine nucleotide metabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine nucleotide metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ACTR2, C2CD3_S2132, and FEN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleotide metabolic process activity versus ACTR2 in LSCC (Pearson r = -0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ACTR2 →	-0.202	-0.042	<.001	<.001	3	6
LSCC	C2CD3_S2132 →	+0.309	+0.021	.004	.004	3	5
LSCC	FEN1 →	+0.440	+0.037	.002	<.001	3	5
COAD	HSD11B1 →	-0.829	-0.060	.005	<.001	2	5
OV	SLC27A4 →	+0.285	+0.030	.002	<.001	3	4
LSCC	HJURP_S486 →	+1.423	+0.039	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006220 vs ACTR2 — LSCC

Explore this scatter interactively →