Pyrimidine nucleotide metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine nucleotide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP2E1, COX6A1, and LMTK3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYP2E1 grouped by Pyrimidine nucleotide metabolic process-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CYP2E1 →	+1.241	+0.188	<.001	.008	2	6
BLOOD_Leukemia	COX6A1 →	+0.739	+0.283	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	LMTK3 →	+1.010	+0.167	.002	.004	2	5
LUNG_NSCLC_LUAD	FUT2 →	+1.161	+0.181	<.001	<.001	3	4
STOMACH	RSPRY1 →	-0.556	-0.210	.003	.008	3	4
BONE	DHODH →	+0.771	+0.339	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYP2E1 by Pyrimidine nucleotide metabolic process activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →