Pyrimidine nucleotide metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine nucleotide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF126, RPS2, and PAXIP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleotide metabolic process activity versus RNF126 in OVARY (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RNF126 →	+0.948	+0.307	.001	.008	3	7
CNS	RPS2 →	+0.931	+0.331	.001	.004	3	6
BLOOD_Leukemia	PAXIP1 →	+0.705	+0.172	<.001	<.001	3	6
SKIN	PKMYT1 →	+0.739	+0.175	<.001	<.001	3	5
BLOOD_Leukemia	USP37 →	+0.765	+0.176	<.001	<.001	3	5
SKIN	POLR2D →	+0.584	+0.222	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006220 vs RNF126 — OVARY

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