Pyrimidine nucleoside metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine nucleoside metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BBS5, CLEC7A, and MAP3K20, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BBS5 grouped by Pyrimidine nucleoside metabolic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	BBS5 →	-0.580	-0.543	.005	.005	3	4
SKIN	CLEC7A →	+0.093	+0.832	.006	.005	3	3
BONE	MAP3K20 →	-1.246	-0.272	<.001	<.001	3	3
OVARY	SLC38A9 →	+0.804	+0.308	.001	.001	2	4
STOMACH	SLCO4A1 →	+2.906	+1.315	.006	.007	3	3
LUNG_NSCLC_LUAD	CCDC184 →	-0.715	-0.747	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BBS5 by Pyrimidine nucleoside metabolic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →