Pyrimidine nucleoside metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine nucleoside metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-C, CAD, and PARP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleoside metabolic process activity versus HLA-C in STOMACH (Pearson r = -0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	HLA-C →	-2.989	-0.426	<.001	.001	3	6
STOMACH	CAD →	+1.324	+0.377	<.001	<.001	3	6
BLOOD_Leukemia	PARP1 →	+0.982	+0.222	.001	.004	3	6
LIVER	LSM12 →	+0.828	+0.352	.004	.002	3	6
SOFT_TISSUE	TMEM265 →	-2.625	-0.455	<.001	<.001	3	5
CNS	RPS2 →	+0.652	+0.250	.005	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006213 vs HLA-C — STOMACH

Explore this scatter interactively →