Pyrimidine nucleobase catabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine nucleobase catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CRMP1, SARM1, and ZNF622_S143, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleobase catabolic process activity versus CRMP1 in BRCA (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CRMP1 →	+0.708	+0.074	<.001	<.001	3	8
UCEC	SARM1 →	+0.489	+0.104	<.001	<.001	3	6
CCRCC	ZNF622_S143 →	-0.944	-0.120	<.001	<.001	3	6
BRCA	GNL2 →	-0.452	-0.061	<.001	<.001	3	6
BRCA	NOC4L →	-0.282	-0.062	<.001	<.001	3	6
BRCA	LUM →	+0.957	+0.081	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006208 vs CRMP1 — BRCA

Explore this scatter interactively →