Pyrimidine nucleobase catabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine nucleobase catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEIS3, NTM, and RNF144A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleobase catabolic process activity versus MEIS3 in OV (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MEIS3 →	+1.188	+0.305	<.001	<.001	3	9
OV	NTM →	+1.267	+0.236	<.001	<.001	3	9
BRCA	RNF144A →	+0.907	+0.227	<.001	<.001	3	9
COAD	JCAD →	+0.846	+0.211	<.001	<.001	3	9
HNSC	PURG →	+0.420	+0.170	<.001	<.001	3	9
OV	PTGIS →	+1.700	+0.249	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006208 vs MEIS3 — OV

Explore this scatter interactively →