Pyrimidine nucleobase metabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine nucleobase metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPP4R2_S226, TACC3_S71, and ARPC3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleobase metabolic process activity versus PPP4R2_S226 in LSCC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PPP4R2_S226 →	+0.807	+0.043	.004	.008	3	6
LUAD	TACC3_S71 →	+0.962	+0.049	<.001	<.001	3	5
LSCC	ARPC3 →	-0.233	-0.055	<.001	<.001	3	5
LSCC	RFC5 →	+0.298	+0.048	<.001	<.001	3	5
LUAD	RIF1_S782 →	+0.662	+0.060	<.001	<.001	3	5
LSCC	SH3KBP1 →	-0.588	-0.069	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006206 vs PPP4R2_S226 — LSCC

Explore this scatter interactively →