Pyrimidine nucleobase metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine nucleobase metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SV2A, THADA, and NECAP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SV2A grouped by Pyrimidine nucleobase metabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SV2A →	-1.699	-0.170	.002	.009	3	6
OESOPHAGUS	THADA →	-0.716	-0.251	.001	.004	3	5
LUNG_SCLC	NECAP2 →	-0.555	-0.505	.004	.001	3	4
KIDNEY	OGDHL →	-2.047	-0.314	.001	.003	3	4
SKIN	MLYCD →	-0.365	-0.268	.003	.006	3	4
OESOPHAGUS	ANTXR1 →	-1.915	-0.315	.006	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SV2A by Pyrimidine nucleobase metabolic process activity — SKIN

Explore this box plot interactively →