IMP catabolic process

Across TCGA patient cohorts, RNA activity of the IMP catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STRBP, ZCRB1, and TRPC6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, IMP catabolic process activity versus STRBP in HNSC (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	STRBP →	-0.595	-0.141	.002	<.001	3	4
BRCA	ZCRB1 →	-0.322	-0.132	.003	.007	3	4
UCEC	TRPC6 →	+0.907	+0.166	.008	<.001	3	4
LSCC	KIF21A →	-0.627	-0.120	.005	.008	3	4
CCRCC	RNU6-641P →	-0.701	-0.186	.001	.002	3	3
CCRCC	RN7SL664P →	+0.431	+0.134	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006204 vs STRBP — HNSC

Explore this scatter interactively →