IMP catabolic process

Across TCGA cell cohorts, RNA activity of the IMP catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2BC13, MSANTD1, and CMC2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, IMP catabolic process activity versus H2BC13 in BREAST (Pearson r = -0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	H2BC13 →	-1.116	-1.419	.002	.002	3	3
BREAST	MSANTD1 →	-0.796	-1.802	<.001	<.001	3	3
BLOOD_Leukemia	CMC2 →	-0.878	-0.813	.002	.002	3	3
LARGE_INTESTINE	SLC2A4RG →	-1.955	-1.337	<.001	<.001	3	3
BLOOD_Leukemia	TMEM116 →	-0.888	-0.780	.003	.008	2	3
BREAST	EIF3L →	+1.090	+1.678	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006204 vs H2BC13 — BREAST

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